Duovir- N is a lamivudine, nevirapine and zidovudine combination drug. It is a first line treatment drug for HIV/AIDS. It is available in monthly doses of two (2) tablets a day.
This flexible combination of two gives room for optioning the choice of Non- nucleoside reverse transcriptase inhibitor (NNRTIs, depending on patient’s treatment rational).
Efavirenz belongs to a class of drugs known as non-nucleoside reverse transcriptase inhibitors (NNRTIs) of HIV-1. It is a non competitive inhibitor of reverse transcriptase and does not significantly inhibit HIV-2 reverse transcriptase or cellular DNA polymerase α, β, γ or δ.
It is recommended that Efavir be taken on an empty stomach, preferably at bed time. The increased concentrations observed after administration of Efavirenz with food may lead to increase in frequency of adverse effects. Dosing at bed time may improve the tolerability of central nervous system symptoms.
This drug contains 200mg of Nevirapine and may be used in combination with other ARV’s for the treatment of HIV infections.
New Antiretrovirals to be manufactured by QCIL
1. Viraday Tablets.
This is a fixed dose triple combination therapy used to treat HIV infection. It contains three antiretrovirals: tenofovir disoproxil fumarate (300mg), efavirenz (600mg), and emtricitabine (200mg). It is a first line treatment for HIV/AIDS recommended by WHO and taken in doses of one pill a day.
2 Tenvir –EM Tablets
The active pharmaceutical ingredient contained in Tenvir–EM Tablets is Emtricitabine 200 mg and Tenofovir Disoproxil Fumarate 300 mg. Tenvir-EM is used in combination with other antiretroviral medications for the treatment of HIV-1 infection in adults. It is also used to treat chronic hepatitis B infection. It is a first line treatment for HIV/AIDS recommended by WHO.
3. Duomune Tablets
Duomune is indicated in combination with at least one other antiretroviral medication for the treatment of HIV infection.It is a fixed dose combination of tenofovir disoproxil fumarate 300mg and lamivudine 300mg.It is a once a day pill.It is recommended by WHO as a first line treatment for HIV infections.